Target Liposome to a Particular Tissue
Liposome is a hollow spherical bilayer, formed when polar lipids agitated in an aqueous medium. Basically, they are colloidal with vesicular structures based on phospholipid bilayers. Their structures depend on the developing procedure and choices of bilayer components. Their length can varied from 20 nm and as large as 190 nm in diameter. The liposomes can be unilamellar, only one bilayer surrounds an aqueous core or multilamellar, where several bilayers concentrically tilting around an aqueous core. Besides that, the choice of bilayer components determines the rigidity and the charge of the bilayer. For example, saturated phospholipids with long acyl chains such as dipalmitoylphosphatidylcholine form a rigid, rather impermeable bilayer structure, while the unsaturated phosphatidylcholine species from natural sources such as egg or soy bean phosphatidylcholine provide more permeable and less stable bilayers. Either positively or negatively charged lipids will
resulted in the liposome’s surface charge. The advantage of liposome is that liposome surfaces can be readily modified by attaching polyethylene glycol (PEG) molecules to the bilayer, the circulation time of liposomes in the blood stream is significantly increased. On the other hand, homing molecules can be attached to liposome bilayers to make these structures target site specific. Parameters that determine the fate of liposomes on the shelf and in vivo are size, lamellarity, bilayer rigidity, charge and bilayer surface modifications. The method that was used is related to the immunoliposomes that are interrelating with a cell surface receptor that is endocytosed, leading to immunoliposome internalisation upon immunoliposome-cell interaction (Daan, et al, 2003). Thus, for a victorious action of the liposome-associated drug, escape from the endosome is vital because many drugs are inactivated when the endosome matures from the endosomal state into a lysoso
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Approximate Word count = 650
Approximate Pages = 3 (250 words per page double spaced)
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