Cancer Cell Physioloogy

Normal Cells have a number of important characteristics. They can reproduce themselves exactly. They can stop reproducing at the right time. They can stick together in the right place. They will self destruct if damaged. They become specialized or mature. Cancer cells differ from normal cells in that they do not stop reproducing. The Cancer cell keeps reproducing itself going on and on doubling. They may be more resistant than normal cells in that they self-dest

Most cancers develop from a single slightly aberrant cell. A single mutation however is not enough to cause cancer. Each mutation causes changes one or a few of the cell properties or characteristics. Cancer develops through an accumulation of changes over time. An example might be that of a colon polyp. The cell acquires mutation that stimulates mild over proliferation of that cell type. The increase in the number of cells causes the likelihood of a second change. This might produce a benign tumor, which might cause a second mutation. This leads to de-differentiated phenotype. Then loss of contact inhibition and further over proliferation happens. This further increases target population for third mutation. It then progresses to a malignant tumor. Once or more further mutations then the cell develops capability to loose adhesion for neighbors in tumor and they break out of the basal lamina migrate to a new location in the body.

Cancer cells actually become immature and start reproducing more quickly and haphazardly. This causes even more cells and spreading of the cancer.

It is amazing to me the new developments in cell and gene manipulation and therapy. It would be amazing to one-day see a cancer cured through cell manipulation. Researchers today are discovering more and more about how to manipulate cancer cells and stop them before they do uncontrol

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