„X Attempted to develop a vaccine against the Streptococcus pneumoniae bacterium
„X He isolated and cultured 2 different strains of the bacterium
„X Some colonies had a rough appearance (R strain)
„X Some had a smooth appearance (S strain)
„X Experimentation revealed that the R strain was harmless and the S strain was pathogenic (disease-causing)
„X Mice injected with live R cells plus heat-killed S cells died; the simplest explanation was that heat killed the S cells but did not destroy their hereditary material
„X Somehow the genetic material had been transferred from the dead S cells to the living R cells
„X They were able to transform harmless bacteria
„X Some enzymes can unwind the strands in both directions and prevent them from rewinding