Hypercholentemia

Bile acid-binding resins lower LDL cholesterol levels. Two resins are available these include choletyramine and cholesterol. Both agents are unusually safe, although constipation, abdominal discomfort, cholestyramine and colestipol may occur. The principal response to bile acid-binding resins is a reduction in LDL cholesterol levels. The bile acid-binding resin lowers LDL cholesterol through a mechanism that ultimately depends on increasing LDL receptors on hepatocytes. The bi

Gemfibrozil (lopid) decrease tiglyceride levels and raises HDL cholesterol levels. Gemfibrozil decreases plasma triglyceride content by lowering VLDL levels. Gemfibrozil is used primarily to reduce high levels of plasma triglycerides. Treatment is limited to patients who have not responded adequately to weight loss and diet modification. Gemfibrozil can be used to raise HDL cholesterol, although it is not approved for this application.

The use of Clofibrate has been discontinued in the United States due to the risks outweighing the benefits. Long-term therapy increases the risk of mortality from cancer and GI disease. It also failed to display proof of mortality from MI.

Fenofibrate (tricor) is indicated for hypertriglyceridemia in patients who have not responded to dietary measures. The most comm

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