Antibiotics may be defined as substances produced by various species of micro organisms (bacteria, fungi, actinomycetes) that suppress the growth of other micro organisms. Common usage often extends the term to include synthetic antimicrobial agents. The idea of this paper is to discuss the use of these antibiotics in Malta. It is unfortunate that in Malta there is a high percentage of misuse of these antibiotics. Such misuse is rampant all over the world, mainly due to the illegal selling of such drugs over the counter (O.V.C) that cause self-administration of these drugs. Other problems faced by the community involve over-use and over-consumption, this being not due to O.V.C only, but also due to the fact that they are highly over-prescribed by the medical professionals in both hospital and private practices. Such over–prescribing is usually due to paranoia on the part of the patient. Recent studies have shown that a majority of antibiotics are being prescribed for viral infections, whilst an even greater number is given for minor colds.Such over use increases the rate of resistance by micro-organisms to the antibiotics, that in the long run casuses the antibiotics to be pulled out of circulation. Problems do not limit