Sickle-Cell Disease is a term that encompasses a group of inherited blood disorders for which Hemoglobin S is the dominant hemoglobin. The featured hallmark of this disease is pain. Although Sickle-Cell Disease can be found in various parts of the world in persons of African, Mediterranean, Middle-Eastern, Asian and East Indian heritage, it predominantly affects African American, African/Hispanic, Caribbean, and South American people in the United States.
Pain in the leading cause of emergency department visits and hospitalization, and is the major focus of home management for people with Sickle-Cell Disease. Severe pain can be experienced as early as six months of age, and can occur unpredictably at varying intervals throughout the course of a person’s life. How pai
▪ Clinicians’ limited knowledge of Sickle-Cell Disease pain, and its
▪ The variability and unpredictability of the acute episodes of pain. (Because of the different states of pain associated with Sickle-Cell Disease and underlying causes, it is very difficult to predict pain.)
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