Glucophage
Polycystic Ovarian Syndrome, or PCOS, is common among five to ten percent of women around child bearing age. It is also the leading cause of infertility in women. Researchers have not yet found a cause for this condition but speculate genetic hereditary as the cause. Some symptoms of PCOS are irregular or absent menstrual periods. The infrequent ovulation in PCOS women produces follicles, 10 mm fluid-filled sacs attached to the ovary which contain the egg. Typically eight or more follicles are formed. (2) Often the follicles are premature which causes them not to ovulate and therefore create cysts on the ovaries. Hyperandrogenism, another symptom, is increased levels of male hormone in the PCOS woman. Other symptoms include infertility, enlarged ovaries, which cause severe pelvic pains, and obesity. (1) Research shows no cure for this disease, merely treatment. The treatments include a cyst removing surgery in which the patient has one month to get pregnant. After a month, the cysts return along with infertility. This is a one time procedure. Another treatment is the drug Glucophage. Glucophage, also known as Metformin Hydrochloride, is commonly used to treat type two diabetes. The drug has only been in the United States sin
Glucophage has not yet been deemed safe or unsafe during pregnancy. As stated above, one of the benefits of the drug is decrease in miscarriages. A study recently showed women taking Glucophage reduced the number of “spontaneous abortions” or miscarriages from 65% to 16%. “Glueck found in a study of 295 women with 328 pregnancies conceived on metformin there have been 185 normal live births without congenital defects (56%), 52 1st trimester spontaneous abortions (16%), and 2 tubal pregnancies (0.6%). Of 89 ongoing pregnancies, 76 are > 13 weeks with normal sonograms (no congenital defects), and 13 are 13 weeks, 261 pregnancies (80%) have a favorable outcome to date. Previously, without Metformin, 145 of these 295 women had 319 pregnancies with 106 (34%) live births and 206 (65%) first trimester spontaneous abortions.” (10) “Until glucophage was introduced, all the available oral glucose-control medications were from the same chemical group called sulfonylureas. These drugs lower blood sugar primarily by causing more of the body's own insulin to be released. glucophage (metformin hydrochloride tablets) lowers the amount of sugar in your blood by helping your body respond better to its own insulin. glucophage does not cause your body to produce more insulin. Therefore, gl
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Syndrome PCOS,
Beneficially Glucophage,
Glucophage Glucophage,
Type II,
Glucophage NN-diethyl,
Previously Metformin,
Metformin Hydrochloride,
Drug Administration,
lactic acidosis,
Polycystic Ovarian,
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295 women,
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13 weeks,
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Approximate Word count = 872
Approximate Pages = 3 (250 words per page double spaced)
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