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Stem Cell Applications

The ongoing research of stem cell biology has introduced possibilities of cellular replacement strategies, which if successful, could create effective treatments for diseases such as Parkinson’s Disease and Diabetes (type 1), as well as repairs to severe spinal chord injuries that were previously untreatable. The medical value of these stem cells is their potential to give rise to any of the tissues contained in the human body. There are currently two sources of stem cells used for research, adult or mature stem cells, and embryonic stem cells; however there is much debate over the use of embryonic stem cells in that some believe it to be a moral equivalent to the killing of one person to benefit another. As will be discussed further, in the case of Parkinson’s Disease through a variety of different methods it is the hope of researchers that the necessary stem cells will become fully functional dopamine neurons. Where Diabetes is concerned it’s the hope that the stem cells will develop into the insulin producing islet cells of the pancreas therefore allowing for the control of the glucose level in the blood. For spinal chord injuries it is the intention of the stem cells to develop into the neurons that carry messages b


In the majority of spinal chord injuries the spinal chord is not actually cut and some of the signal carrying neuronal axons are still intact. However, the axons no longer carry messages to the brain because cells called oligodendrocytes (cells that make the axons’ insulating myelin sheath) are lost. Researchers have shown that through the injection of oligodendrocytes derived from mouse embryonic stem cells the axons could remyelinate, and as a result the treated mice regained limited use of their limbs. (Stem Cells: Scientific Progress and Future Research Directions, 2001, p. 84)

Over the last 10 years scientists have been experimenting with transplanting neuronal cells from a donor to the Parkinson’s infected patient, however this method has had limited success in that obtaining the significant number of cells needed for implantation is extremely difficult and often unlikely. (Chemistry & Industry, No. 5, p. 133) What researchers are hoping to find in stem cells is a renewable source that can operate as dopamine neurons. As of now, laboratory grown cells derived from a stem cell is the best potential source. One way to get these cells to the point of dopamine production is to find the right combination of growth factors and cell-culture conditions where they are actually committed to be dopamine neurons and then injecting them directly into the brain. Another method is to place less committed cells into a damaged brain and rely on “environmental” signals to guide the cell into becoming a dopamine neuron. (Stem Cells: Scientific Progress and Future Research Directions, 2001, p.83) Present research has shown that both human fetal cells and embryonic stem cells can become fully functional dopamine neurons; however whether adult stem cells will have a similar effect is presently unknown.

Stem cell research holds the potential of curing previously incurable diseases such as Parkinson’s disease, and Diabetes (type 1), and gives hope to sufferers of spinal chord injuries that they will one day regain feeling in some, if not all, parts of their body. Through the simple manipulation and implantation of cells doctors and researchers are on the way to gaining the ability to repair whatever malfunction of whatever bodily processes, or lack there of, are taking place and causing these horrible diseases and disabilities. Engrained within this research are several moral and ethical debates pertaining to the use of embryonic stem cells, as well as several unknowns as to the possible side effects of the treatments which are causing many to disregard this research as incomplete, and therefore irrelevant. Although stem cell research is still very much in its infancy, and any practical applications to human subjects are years away, the research on this subject must continue. Stem cell research could prove to be the key to eliminating physical disabilities and many diseases that were previously incurable; therefore it is imperative that doctors and researchers not shrink from doing what will advance knowledge in this area, and eventually add to our quality of life for now, and for centuries to come.

Researchers of Parkinson’s disease are also searching for way to ignite the stem cell repair mechanisms already in a patient’s brain to fix the problems the mechanisms couldn’t otherwise manage. In a study conducted by James Fallon and colleagues it was discovered that by injecting a protein called transforming growth factor (TGFa) it will trigger the brain’s repair process, which is othe

Some topics in this essay:
Chemistry Industry, Research Directions, Parkinson’s Disease, Dr Yang, Tarcisco Barros, Stem-Cell Debate, Sam Pfaff, Lijun Yang, Cardion Inc, Disease Diabetes, stem cells, stem cell, embryonic stem cells, embryonic stem, stem cell research, cell research, adult stem cells, spinal chord, adult stem, chord injuries, parkinson’s disease, spinal chord injuries, research directions 2001, progress future, chemistry industry,

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Approximate Word count = 2380
Approximate Pages = 10 (250 words per page double spaced)


  

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