1. Leptin
... deficiency. Furthermore, this is supported by observations that Ob-Rb and NPY are coexpressed in the ARC. Also, leptin inhibited NPY expression in ob/ob mice and in normal mice as well as possibly regulating the availability of NPY for release. Not only in NPY neurons, but the OB-Rb receptor has also be located on POMC (precursor forendorphin)- and galanin-containing neurons ... appears to accelerate reproductive maturation in women and cause an earlier onset of the oestrous cycle, and in men, a surge of leptin is seen in at the onset of puberty. In this context, leptin may act to signal ...
- Word Count: 3450
- Approx Pages: 14
- Grade Level: Undergraduate