1. Developmental Dyslexia and Genetic Mutations
... the receptor involved in cognitive processes and memory. Using co-localization, co-immunoprecipitation and proximity ligation assays, DYX1C1 was shown to have estrogen receptors that interact with estrogen in the nucleus. (10) Massinen et al found that Erβ knock-out (KO) mice present very similar phenotypes as the post-mortem brains of dyslexic individuals. Hatakeyama et al. showed that DYX1C1 interacts with the ... the wild type, the Erβ had a 3 times more expression of the gene (fig2)(9) Thus, Estrogen was proven to interact with DYX1C1 through the Erβ pathway in the nucleosome and...
- Word Count: 2290
- Approx Pages: 9
- Has Bibliography
- Grade Level: Undergraduate