... the tissue-specific transcription factors CEBPA and HNF4A among human, mouse, dog, opossum, and chicken. Although tens of thousands of binding events are found in each individual species and the DNA binding preferences of the transcription factors are highly conserved, most binding is species-specific. For example, any two of the three placental mammals we analyzed shared 10 to 20% of ... binding events that we observed. The loss of the majority of binding events can be explained by disruption of the transcription factor's binding motif as a result of changes in the DNA sequence, wherea...

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