... My Ph.D. thesis extended these prior analyses by comparing in vivo binding of the tissue-specific transcription factors CEBPA and HNF4A among human, mouse, dog, opossum, and chicken. Although tens of thousands of binding events are found in each individual species and the DNA binding preferences of the transcription factors are highly conserved, most binding is species-specific. For example, any ... genetic mechanisms underlying the rapid gain and loss of binding events that we observed. The loss of the majority of binding events can be explained by disruption of the transcription factor...

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• Grade Level: Graduate