... causes thickening of artery walls. The thickening usually starts in individuals after age 20. These fibrous plaques or lesions usually produce localized narrowing in the proximal portions of the major coronary arteries. The blood supply to the myocardium can be impeded by several mechanisms: the lesion creates a fixed obstruction so that blood flow through the artery cannot increase in response ... to demands, the vessel lumen becomes completely occluded, or portions of clot or plaque embolize. The growth of obstructive lesions in the coronary arteries cause other blood vessels to provid...

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