... mostly from the contraction of the muscle under anaerobic conditions, which causes a build-up of lactic acid in the muscle and the blood. The increased acidity changes the activity of glycolytic enzymes and interferes with the cross-bridge cycle. Fatigue also involves a depletion of glycogen stores in the liver as well as in the muscle that is being exercised. As ... have a sarcoplasmic reticulum; during a contraction, Ca++ enters from the extracellular fluid. In the cytoplasm, Ca++ binds to calmodulin (protein structurally similar to troponin). The Ca++ calmodulin complex activates the...

• Word Count: 9019
• Approx Pages: 36
• Has Bibliography
• Grade Level: Undergraduate