1. Cardiovascular diseases
... enter a ruptured atheroma, making it larger, so that it narrows the artery even more. A ruptured atheroma also may spill its fatty contents and trigger the formation of a blood clot (thrombus). The clot may further narrow or even occlude the artery, or it may detach and float downstream where it causes an occlusion (embolism). Usually, atherosclerosis doesn't produce symptoms until it severely ... pumping ability (a larger heart beats more forcefully). The enlargement also may reflect the heart muscle damage itself. Enlargement after a heart attack suggests a worse prognosis than a norm...
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