The human body stores creatine, primarily in the skeletal muscles (95% of complete creatine content) and the remaining tends to be in the brain, heart and testes (Flanagan, 2007 and Cooper et al., 2012). Averagely, around 120 grams of creatine is stored in the skeletal muscles of an 70kg person, with two thirds of this stored in the form of phosphocreatine (PCr) and the remaining third stored as free form creatine (Burford et al., 2007).
Creatine supplementation response does vary between individuals. The variation tends to be from around a 10-40% increase in creatine stores within the body (Burford et al., 2007, Syrotuik and Bell, 2004, Arazi et al., 2011, Sculthorpe et al., 2010 and Jagim et al., 2012). However, Syrotuik and Bell (2004) contradicts this, by providing information, concluding that 20-30% of individuals have 0% increase in creatine stores, showing no response to creatine supplementation, however the due to the small sample size, the results could be considered inconclusive and aren't supported by many other journal results. Furthering this Cooper et al., (2012) also mentions that multiple studies have also resulted with creatine supplementation not affecting strength performance, however this is vague information on the overall effectiveness on creatine supplementation. An individual's pre-creatine supplementation content and the individual's body mass play a big part in the percentage increase of stored creatine within the body. Burford et al. (2007) and Flanagan (date unknown), argue that those of whom' live of little beef and fish, will tend to be more responding to the supplementation of creatine due to the vast increase they'll be receiving from the diet, whereas those who do eat larger quantities of beef and fish with be less responsive due to already having a more effective/larger creatine pool. Due to the results and information given in Burford et al. (2007), Syrotuik and Bell (2004), Arazi et al.