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Genetic Disorder - Haemophilia

            Genetic Disorder Introduction .
             Genetic Disease or disorder is a change that occurs in each individual's DNA that makes up the gene. A disorder results when a gene is mutated and the protein product can no longer perform its normal function. They can be inherited because they are a change in the germ cells which passes the genetic information from parents to its offspring. Also it can have changes in the DNA in somatic cells or in other body cells; mostly it doesn't has to be the in germ cells. These disorders are caused by the mutations in the sequence of single gene. Most of the genetic diseases are multifactorial which caused by the mutations in many other genes lead by the environmental issues. Such as heart diseases, cancer and diabetes. .
             Is Haemophilia Inherited? .
             Haemophilia is inherited in the pattern of X-linked. This is because when gene mutation occurs is located in the X chromosome which is one of the two sex chromosomes. In males who have only one X chromosome and one copy of the gene is enough to cause the genetic condition. However, in females who have two X chromosomes mutation must occur in the both copies of the genes to cause haemophilia. The crucial characteristic of X lined inheritance is that males cannot pass down their X- linked traits to their sons. For example if a female is a carrier, she has one in two precent to pass on her X chromosomes with the gene mutation for haemophilia A or B to a boy. Whereas, she might not be able to pass the X chromosome to her boy with the normal functioning gene. So above all, she has a fifty percent of chance of infecting her child of haemophilia. .
             Inheritance of Haemophilia.
             This disease is inherited condition which occurs in family, whereas in one third of cases show it appears in families with no previous history of the haemophilia disorder.

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