The relationship between the play within the play, "Pyramus and Thisbe" and A Midsummer Night's Dream becomes significant after all is revealed when the mechanicals present their play for the wedding ceremony. The play, in some ways, symbolizes the relationships between all of the couples. They would go to extremes for each other because of their love for each other. .
Pyramus and Thisbe can be compared to several couples in this story, and each of these couples had the ability to end up as Pyramus and Thisbe did if situations had not played out as they did. All these couples are used to show the trials, tribulations and triumphs of lovers. Each of the couples have their different roles in the play.
Theseus and Hippolyta, at one time, hated each other but at the beginning of the ply are waiting to be wed. The major conflict begins as a lone triangle that soon includes a fourth member. Demetrius, who is in love with Hermia but Hermia, is devoted to Lysander who returns Hermia's love. All three are brought to the Duke's court by Egeus, Hermia's father who wants her to marry Demetrius. Egeus is willing to have his daughter killed if she does not marry Demetrius. .
Hermia's childhood friend, Helena, becomes the fourth in this group because she desperately pursues Demetrius, who won't give her a second glance while blinded by his love for her friend Hermia. Hermia runs away to the woods and defies her father with plans to marry Lysander. Her love is blinded by her own arrogance much as the love of Pyramus and Thisbe are "blinded" by the wall.
Demetrius and Helena are in the same boat with Hermia and Lysander. Their love can be said to have" blinded" by all the criticism they go through from their parents. The want so much to be together that they are willing to run away from home and risk everything they have for each other. Pyramus and Thisbe are the same in that they have the same undying love for each other that they are willing to take any plunge, even death, if they have to be apart.