1. Health Promotion Asthma
... release of cytokines by mast cells, T-cells, fibroblasts, endothelial and epithelial cells, in turn, activates neutrophils, eosinophils and macrophages, which produce the chronic allergic inflammation characteristic of asthma Holgate (1999:27). Cytokines can also modulate smooth muscle responsiveness, modulate vascular permeability, activate neurons and stimulate mucus secretion. These effects can lead to the structural changes in ... muscle; and thickening of the airway wall as a result of new vessel formation, increased numbers of epithelial goblet cells, and deposition of interstitial...
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