1. Developing Treatments for Cancer
... approach on the growth inhibition of tumor cell lines. Gleevec was originally derived from a lead compound detected in a screening for inhibitors of protein kinase C (Capdeville et al.: 2002). The identified lead compound was observed to have a high potential for diversity and thus susceptible to chemical change to produce a compound greater in its effectiveness and selectivity for desired targets. The chemical optimization of the ... compound ultimately led to the imatinib compound (Gleevec) classified as a small molecule tyrosine kinase inhibitor. Gleevec was first demonstrated to exh...
- Word Count: 1146
- Approx Pages: 5
- Has Bibliography
- Grade Level: Graduate