1. Cloning
In 1938, Hans Speman proposed cloning a mammal by transplanting an adult cell's nucleus into a fertilized egg. ... Using this process, nuclear DNA from the body cell of a donor frog was injected into the egg cell of a recipient frog whose nuclear genetic material was removed. The fused cells divided just like a normal fertilized egg and formed an embryo that was genetically identical to the donor frog. ... The key to this new procedure was to time the cell cycle of the mammary cell with that of the egg. ... The nucleus of the mammary cell was transferred into the recipient egg. ...
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