These symptoms are called eyelid edema and chemosis (Thong, 2013). The trunk, face, palms, and soles are the initial sites of erythema and erosions of the skin (Harr & French, 2010). The rashes are considerably broad, extensive, and untypically warm. The skin starts to sag because of the fluid developing under the dermal layer, and eventually there is an epidermal detachment (Tiwari et al., 2013). .
Harr and French (2010) reported that in the late phase some of the sequelae are hyper and hypopigmentation; that is, the skin is either lighter or darker from the original color, and nail dystophies (Harr & French, 2010). Commonly 90% of the victim's mucous membranes are implicated, and these sites are the genital, oral, and ocular (Law & Leung, 2014). Some of the ocular complications include harshly dry eyes; ingrown eyelashes, which is known as trichiasis; symblepharon, adhesion of the eyelid; distichiasis, which is when the eyelash arises from an abnormal spot on the eyelid; loss of vision; eyelid falling forward, also known as entropion; adhesion of the ciliary edges of the eyelids to each other, which is ankyloblepharon; the eyes' inability to fully close, which is known as lagophthalmos; and ulceration of the cornea. Keratoconjunctiviitis that is the inflammation of the cornea and conjunctiva can also manifest as well as xerostomia, dryness of the mouth (Harr & French, 2010). .
C. Diagnostic Tests .
The method of diagnosis for TEN is dependent on the clinical symptoms, such as erythematous and changes in the color of the skin. A test for a Nikolsky sign is administered (Harr & French, 2010). When pressure is placed on the skin, such as with a slight rub, and the superficial layer of the skin comes off of the deeper layer of the skin, it is a positive Nikolsky sign. A pencil or an eraser may be rubbed back and forth around the area of the skin, and the appearance of blisters is a positive Nikolsky sign.