In this experiment, we conduct the synthesis of aspirin, reinforce the skills of recrystallization and the technique of melting point determination. The procedure goes as follows: Weigh 2.4g of salicylic acid in a conical flask. Then add 6mL of acetic anhydride to the acid. Add 3-4 drops of conc. sulfuric acid and swirl. Heat the mixture in water bath for 10mins. Add a drop of distilled water to decompose the excess acetic anhydride. Add 40mL of cold water. Stir and collect the crude product by suction filtration. .
Since the crude product is impure, recrystallization is required. Dissolve the crude product in 5mL of ethanol in a conical flask. Further add in 30mL of hot distilled water. Warm until all of the solid dissolves in the solution completely. Allow it to cool. Using the weighed filter paper, obtain the recrystallized product by suction filtration. Transfer the crystals and filter paper onto the weighed watch glass. Dry them in the oven (100°C) for 15mins. Once done, desiccate it for 5mins. Weigh everything and record this weight. The weight is 35.9845g. The weight of the dried, recrystallized aspirin is 1.0071g. The expected yield of aspirin is 3.132g. The percentage yield is 32.2%.
2. Introduction .
1. The History of Aspirin.
Also known as acetylsalicylic acid, was founded nearly in the 1800s. Before the time of Columbus, the Native Americans drank teas made from the bark of the willow to reduce fever. In the early 1800s, the active ingredient in the willow bark was isolated and identified as salicylic acid. After a while, this acid was being synthesised in the laboratory. Acetylsalicylic acid was first discovered by Arthur Eichengruen, Felix Hoffman's supervisor, in the early 1930s. Hoffman was a chemist, working for the Bayer Laboratories in Germany. For many years, it was assumed that it was Hoffman who discovered this acid. But Eichengruen's name was removed due to the fact that he was a Jew and at that very time Nazi Party came to power in Germany.
Aspirin Aspirin, which is made by Bayer, is a pain reliever that temporarily relieves headaches, painful discomfort and fever of colds, and inflammation caused by various conditions. ... Aspirin costs $7.99 for 100 tablets. ... However, Aspirin may be used under doctor supervision for children. ... Pregnant women should take aspirin only under doctor surveillance. ... Diabetics and people with gout should avoid Aspirin. ...
Aspirin is prepared by acetylation of salicylic acid with acetic anhydride. ... Aspirin is excreted as a glucuronide, salicyuric acid, or gentisic acid. ... Aspirin is effective as an analgesic, antipyretic and anti-inflammatory drug. ... Aspirin lowers fever, probably by acting on the hypothalamus. ... Intolerance to aspirin is not uncommon. ...
He may give you aspirin as a blood thinner and an anti-inflammatory. ... Take aspirin. If you're not allergic to aspirin, consider taking an aspirin just before a long trip. Aspirin interferes with your blood's clotting action. ... Aspirin reduces the tendency of your blood to clot by reducing the clumping of your platelets. ...
It is effective orally and is marketed in combination with aspirin (Percodan) or acetaminophen (Percocet) for the relief of pain. ... It contains pure oxycodone without aspirin or Tylenol in it. In preparations that do include aspirin or Tylenol, usually the high contents of these additives will be toxic to the addicted patient before the narcotic itself is. ...
My lack of preparation led to not winning any races on the track. ... In order to achieve physical preparation, I needed to become more fit. ... Without physical preparation it is near impossible to be mentally prepared. ... It takes preparation to ready all your muscles to come back strong. ... I need both, perseverance and preparation, if I ever plan on racing professionally. ...
Drug Class All of us have used drugs at one time or another whether it's aspirin, pot or narcotics. Do we all belong in jail? The answer is no. Society has designed a system to separate the wide variety of drugs that people use and categories for different people that use them. I think it's ...
Today, morphine is marketed in a variety of forms, including oral solutions, immediate and sustained-release tablets and capsules, suppositories, and injectable preparations. In addition, the availability of high-concentration morphine preparations (i.e., 20-mg/ml oral solutions, 25-mg/ml injectable solutions, and 200-mg sustained-release tablets) partially reflects the use of this substance for chronic pain management in opiate-tolerant patients. ... It is made into tablets either alone (Schedule II) or in combination with aspirin or acetaminophen (i.e., Tylenol with Codeine, Schedule III)...
