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Sickle Cell Disease

            Sickle Cell disease is a disorder passed down through families, where it causes red blood cells to become abnormally shaped. Red blood cells are the cells that transports or carries oxygen throughout the human body. Sickle Cell disease affects over 400,000 children and adults per year. This genetic disorder is a very deadly one and causes symptoms that eventually lead to a very serious injury or even death. The disease gets its name from the abnormal shape of the affected red blood cells. The only way you can get sickle cell disorder is if both your parents pass down one defective copy of the disease. The parents can be carriers of the defective sickle cell gene and not have the disease, nor have any symptoms. The only way they would know they were carriers is if they had taken a sickle cell trait blood test. Sickle cell disease is inherited in an autosomal recessive pattern which means two copies of the abnormal gene must be present in order to develop the disorder. People with sickle cell disease have a gene abnormality or a mutation of the hemoglobin gene in chromosome 11. Hemoglobin is a molecule in the red blood cell that delivers and carriers oxygen to cells throughout the human body. In the hemoglobin there are four protein subunits: 2 subunits of alpha globin and 2 subunits of beta globin. The mutations in the hemoglobin occur in the HBB gene. This gene provides instructions for making beta globin. In sickle disease at least one of the beta globin subunits is replaced with hemoglobin S. Abnormal versions of beta globin can distort red blood cells into a sickle shape. The sickled blood cells can lead to anemia.
             Sickle cell disease or disorder cause a number of symptoms. These symptoms often lead to a serious injury or death in a patient. The most common effect is the sickling of blood cells, this means that the red blood cells are oddly shaped. This symptom is the root cause for all the other symptoms.


Essays Related to Sickle Cell Disease

1. Sickle Cell

... it leukemia, cancer, can it be caught through contact, same as a cold? NO! Sickle Cell is a condition, which is inherited from both parents. A person that has Sickle Cell inherits abnormal hemoglobin (Hb) from both parents who may be carriers with the sickle cell trait or with sickle cell disease. Sickle Cell affects the red blood cells, which contain the special protein called hemoglobin (Hb), which is ... . There also are prenatal tests to determine whether the baby will have sickle cell disease, carry the trait or be unaffected. If both parents have the sickle cell trait, in three ou...

  • Word Count: 1542
  • Approx Pages: 6
  • Has Bibliography
  • Grade Level: Undergraduate

2. Sickle Cell Anemia

... According to some research, the most common forms, or variations of Sickle Cell Anemia are homozygous (hemoglobin SS disease), heterozygous sickle cell hemoglobin C disease (hemoglobin SC disease), and the sickle Beta-thalassemia. Children and adults with homozygous sickle cell disease inherit a sickle cell (S) gene from each of their parents, and shows all the signs and symptoms of Sickle Cell Anemia, such as painful joints, chest pain, and kidney problems. ... and people of the Mediterranean are very careful about who they marry and have children with. Carriers or people with no histo...

  • Word Count: 2318
  • Approx Pages: 9

3. Sickle Cell Anemia

... According to some research, the most common forms, or variations of Sickle Cell Anemia are homozygous (hemoglobin SS disease), heterozygous sickle cell hemoglobin C disease (hemoglobin SC disease), and the sickle Beta-thalassemia. Children and adults with homozygous sickle cell disease inherit a sickle cell (S) gene from each of their parents, and shows all the signs and symptoms of Sickle Cell Anemia, such as painful joints, chest pain, and kidney problems. ... and people of the Mediterranean are very careful about who they marry and have children with. Carriers or people with no histo...

  • Word Count: 1886
  • Approx Pages: 8

4. Sickle Cell Anemia

... Sometimes the child experiences the physical states of being retarded, and sexual development. Later in life, they may experience complications in pregnancy. (Krauss 1) When a child is diagnosed with sickle cell disease, it is important to have them receive the regular vaccinations. Hib (Hemophilus influenza b) is one of the vaccinations. This is recommended for all babies starting at two months old. It ... stimulating the production of fetal hemoglobin, which is present in the fetus and in newborn babies. This should prevent the cells to become rigid. In the near future, The Sickle Cel...

  • Word Count: 2222
  • Approx Pages: 9
  • Has Bibliography
  • Grade Level: High School

5. Sickle-Cell

... causes Sickle Cell? B. What comes from Sickle Cell? C. How can you tell if you have Sickle Cell III. Sickle Cell in newborns A. A test for newborns B. The traits IV. Sickle Cell being passes down A. The mother or father passes it on B. Sickle Cell and genes V. Can it be controlled. A. Ways to stay healthy. B. Staying healthy with Sickle Cell VI. What to watch for A. What can signal a flare up B. What may come from Sickle Cell Sickle Cell Anemia Sickle Cell Anemia is a disease ... found commonly in African-Americans. Sickle Cell is a form of ... ...

  • Word Count: 1566
  • Approx Pages: 6
  • Has Bibliography
  • Grade Level: High School

6. Sickle Cell Anemia

... red cells, and cells containing fetal hemoglobin tend to survive longer in the bloodstream. One approach to treating sickle cell disease is to rekindle production of fetal hemoglobin. The drug, hydroxyurea induces fetal hemoglobin production in some patients with sickle cell disease and improves condition of patients (FDA Consumer). There is some evidence that administering hydroxyurea with erythropoietin, a ... genetically engineered hormone that stimulates red cell production, may make hydroxyurea work better. This combination approach offers the possibility that lower ... spleen fun...

  • Word Count: 2447
  • Approx Pages: 10
  • Grade Level: Undergraduate

7. Sickle Cell Anemia

... red cells, and cells containing fetal hemoglobin tend to survive longer in the bloodstream. One approach to treating sickle cell disease is to rekindle production of fetal hemoglobin. The drug, hydroxyurea induces fetal hemoglobin production in some patients with sickle cell disease and improves condition of patients (FDA Consumer). There is some evidence that administering hydroxyurea with erythropoietin, a ... genetically engineered hormone that stimulates red cell production, may make hydroxyurea work better. This combination approach offers the possibility that lower ... spleen fun...

  • Word Count: 2447
  • Approx Pages: 10
  • Grade Level: Undergraduate

8. Sickle Cell Anemia

... red cells, and cells containing fetal hemoglobin tend to survive longer in the bloodstream. One approach to treating sickle cell disease is to rekindle production of fetal hemoglobin. The drug, hydroxyurea induces fetal hemoglobin production in some patients with sickle cell disease and improves condition of patients (FDA Consumer). There is some evidence that administering hydroxyurea with erythropoietin, a ... genetically engineered hormone that stimulates red cell production, may make hydroxyurea work better. This combination approach offers the possibility that lower ... spleen fun...

  • Word Count: 2447
  • Approx Pages: 10
  • Grade Level: Undergraduate

9. Sickle Cell Disease

... hemoglobin from your parents, who may be carriers with sickle cell trait or parents with sickle cell disease. You cannot catch it. You are born with the sickle cell hemoglobin and it is present for life. If you inherit only one sickle gene, you have sickle cell trait. If you inherit two sickle cell genes you have sickle cell disease. Sickle cell trait is a person who carries one sickle hemoglobin producing gene inherited from their parents and one ... normal hemoglobin gene. Normal hemoglobin is called type A. Sickle hemoglobin called S. Sickle cell trait is the presence of hemoglobin A...

  • Word Count: 1507
  • Approx Pages: 6
  • Grade Level: High School

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