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Sickle Cell Disease

            Sickle Cell disease is a disorder passed down through families, where it causes red blood cells to become abnormally shaped. Red blood cells are the cells that transports or carries oxygen throughout the human body. Sickle Cell disease affects over 400,000 children and adults per year. This genetic disorder is a very deadly one and causes symptoms that eventually lead to a very serious injury or even death. The disease gets its name from the abnormal shape of the affected red blood cells. The only way you can get sickle cell disorder is if both your parents pass down one defective copy of the disease. The parents can be carriers of the defective sickle cell gene and not have the disease, nor have any symptoms. The only way they would know they were carriers is if they had taken a sickle cell trait blood test. Sickle cell disease is inherited in an autosomal recessive pattern which means two copies of the abnormal gene must be present in order to develop the disorder. People with sickle cell disease have a gene abnormality or a mutation of the hemoglobin gene in chromosome 11. Hemoglobin is a molecule in the red blood cell that delivers and carriers oxygen to cells throughout the human body. In the hemoglobin there are four protein subunits: 2 subunits of alpha globin and 2 subunits of beta globin. The mutations in the hemoglobin occur in the HBB gene. This gene provides instructions for making beta globin. In sickle disease at least one of the beta globin subunits is replaced with hemoglobin S. Abnormal versions of beta globin can distort red blood cells into a sickle shape. The sickled blood cells can lead to anemia.
             Sickle cell disease or disorder cause a number of symptoms. These symptoms often lead to a serious injury or death in a patient. The most common effect is the sickling of blood cells, this means that the red blood cells are oddly shaped. This symptom is the root cause for all the other symptoms.


Essays Related to Sickle Cell Disease

1. sickle cell disease

The genetic disorder I was told to research was the Sickle Cell Disease. ... The Sickle Cell Disease is an inherited disease. ... There are many complications and harmful effects as the result of the Sickle Cell Disease. ... The most painful effect known from Sickle Cell Disease are episodes of pain called Sickle Cell Crisis, where the body is in need of oxygen, either from physical activities or a sickle blood cell blocking blood passages that lead to organs. ... To try to ease the pain caused by Sickle Cell Disease, a substance that can prevent red blood cells from sickling without causing h...

  • Word Count: 547
  • Approx Pages: 2

2. Sickle-Cell Disease (SCD) and

Sickle-Cell Disease is a term that encompasses a group of inherited blood disorders for which Hemoglobin S is the dominant hemoglobin. ... Pain in the leading cause of emergency department visits and hospitalization, and is the major focus of home management for people with Sickle-Cell Disease. ... It is probably best to first recognize the need for adequate assessment and management of Sickle-Cell pain. There are, however, some barriers that affect the understanding of this disease such as: ▪ Clinicians" limited knowledge of Sickle-Cell Disease pain, and its management. ... Opi...

  • Word Count: 525
  • Approx Pages: 2
  • Grade Level: Undergraduate

3. The agony of Sickle Cell Anemia

Each and every day tens of thousands of people worldwide suffer from a disease known as sickle-cell anemia. ... Sickle-cell disease is caused by a genetic defect in the hemoglobin molecules. The disease is triggered when red blood cells become deprived of oxygen, therefore resulting in sickle-shaped, rigid, and sticky blood cells that are unable to squeeze through capillaries. ... Bone marrow transplantation has been shown to provide a cure for severely affected children with sickle cell disease. ... Sickle-cell anemia is a tragic disease that takes over the body of its victims. ...

  • Word Count: 969
  • Approx Pages: 4
  • Has Bibliography
  • Grade Level: High School

4. Sickle-Cell

Sickle Cell Anemia Thesis: After examining my disease of Sickle Cell Anemia I have found out new information about the disease I. What is Sickle Cell? ... What causes Sickle Cell? ... What may come from Sickle Cell Sickle Cell Anemia Sickle Cell Anemia is a disease found commonly in African-Americans. ... Although there is an up side to having the disease, at least if you were to live in Africa where the disease Malaria was very common the gene inherited disease of Sickle Cell Anemia helped to fight off the insect carrying disease of Malaria, which is so common in Africa as is Sickl...

  • Word Count: 1566
  • Approx Pages: 6
  • Has Bibliography
  • Grade Level: High School

5. Sickle Cell Anemia and Cell Disease

It will focus on what sickle cell anemia is, how a person may obtain or transfer this disease, and the function of cells carrying sickle cell anemia. I have chosen to do research on sickle cell anemia because I am a carrier of this disease. ... Sickle Cell Anemia/ Sickle Cell Disease Definition "Sickle cell anemia (SCA) is an inherited form of anemia- a condition in which there is not enough healthy red blood cells to carry adequate oxygen throughout your body" (Mayo Clinic Staff). ... Conclusion Sickle cell anemia is one of the most life threatening diseases. ... Sickle cell anemia...

  • Word Count: 937
  • Approx Pages: 4
  • Has Bibliography
  • Grade Level: High School

6. Sickle Cell Disease

Sickle Cell Disease is a group of inherited red blood cell disorders. ... When two sickle cell genes are passed, it is called sickle cell disease. ... Caucasians can also have sickle cell disease or trait. ... Complications from sickle cell disease include: !) ... The only cure today for sickle cell disease is a bone marrow transplant to replace the "factory" that makes the red blood cells with a matched donor, usually a sibling without sickle cell disease. ...

  • Word Count: 565
  • Approx Pages: 2
  • Grade Level: High School

7. sickle cell anemia

Sickle cell anemia is a red blood cell disorder, in which instead of being like normal round cells, affected blood becomes hard sticky, and shaped like sickles, clogging blood flow and breaking apart. ... Caucasians also have sickle cell disease or trait. (5) In the United States, sickle cell anemia is most common among African Americans. ... There are three common types of sickle cell diseases in the United States; ( Hemoglobin SS or sickle cell anemia, Hemoglobin SC disease, and sickle beta - thalassemia.) ... This test will tell if an individual is a carrier of the sickle cell trait ...

  • Word Count: 1325
  • Approx Pages: 5
  • Grade Level: High School

8. Sickle cell anemia

Sickle cell anemia is a red blood cell disorder, in which instead of being like normal round cells, affected blood becomes hard sticky, and shaped like sickles, clogging blood flow and breaking apart. ... Caucasians also have sickle cell disease or trait. (5) In the United States, sickle cell anemia is most common among African Americans. ... There are three common types of sickle cell diseases in the United States; ( Hemoglobin SS or sickle cell anemia, Hemoglobin SC disease, and sickle beta - thalassemia.) ... This test will tell if an individual is a carrier of the sickle cell trait ...

  • Word Count: 1316
  • Approx Pages: 5
  • Grade Level: High School

9. Sickle Cell Disease

Sickle Cell Disease Sickle Cell Disease is a group of inherited red blood cell disorders. ... You inherit the abnormal hemoglobin from your parents, who may be carriers with sickle cell trait or parents with sickle cell disease. ... If you inherit two sickle cell genes you have sickle cell disease. ... This will not cause sickle cell disease. ... There are different types of sickle cell disease. ...

  • Word Count: 1507
  • Approx Pages: 6
  • Grade Level: High School

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