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Systemic Lupus Erythematosus

            Systemic Lupus Erythematosus is one of the classic examples of autoimmune diseases among human beings. Clinically it is an unpredictable remitting, relapsing disease of acute onset that may involve virtually any organ in the body; however it principally effects the skin, kidney, serosal membranes, joints and heart. There are no strict symptoms of SLE however weakness, fatigue, weight loss, pain headache and skin rash are few of the very commonly observed symptoms (Price et al, 2002).In last couple of years many scientists have shown keen interest in exploring the disease to the depths of molecular level. Three important areas of their studies are: 1- Role of gender in acquiring Systemic Lupus Erythematosus. 2- Autoantibodies associated with the disease. 3- Role of certain lymphokines and T cells in the development and acquiring of disease. .
             It was long ago observed that Systemic Lupus was far more common in females than males, approximately with a ratio of 9:1(Rider et al, 1998). Several theories were proposed to explain the existence of the phenomenon. The explanation that gained most popularity and acceptance was the one give by Dr. Rider with the team at University of Missouri-Kansas. Dr. Rider proposed hormonal influence in the having and carrying of disease (Rider et al, 1998). Twelve SLE patients were tested against nine normal female patients. Blood samples were obtained at certain interval of time from both the normal and the diseased individuals, T cell population obtained were very carefully analyzed and observed. The obtained samples were clinically analyzed through series of tests. And it was shown that estrogen was the key factor. This experiment presented the early idea of a mechanism by which estrogen plays a role in gender difference in a disease like Systemic Lupus Erythomatsus. The data and observations obtained from the experiment suggest that Estrogen increases the expression of intracellular calcineurin in patients suffering from SLE evident by increased sensitivity of the T cell population obtained from the diseased individual, where as the T cell population obtained from the normal individuals did not exhibited any such sensitivity.


Essays Related to Systemic Lupus Erythematosus

1. Symptoms and Treatments of Lupus

... months to years. In lupus, something goes wrong with the body's immune system, which is the part of the body that fights off viruses, bacteria, and germs (Lupus Foundation of America, 2011). There are several types of lupus such as drug-induced lupus, subacute cutaneous lupus erythematosus, discoid lupus erythematosus, and systemic lupus erythematosus. Of the four types, systemic lupus erythematosus is found to be ... the most common ("Womens Health", 2009). Etiology (causal factors) Lupus is not a contagious disease, in other ... they report that the disease has reduced their working h...

  • Word Count: 2820
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  • Has Bibliography
  • Grade Level: High School

2. The History Of Lupus

Introduction There is no more difficult disease to diagnose, understand, or treat than the disease called systemic lupus erythematosus (Lahita 1998). This may be due to the fact that lupus is not one disease but many diseases grouped under one heading. I t may also be because the disease can present itself to both physicians and patients in mysterious ways; throwing them ... may also be a rash. The rash may be associated with recent sun exposure and is usually located on the face or arms (Lahita 1998). Over half of the patients with systemic lupus develop a characteristic red, flat facial ra...

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3. Lupus

... flu, and even stress help to form lupus. Together or separate these factor all seem to contribute to the cause, but scientists have to yet to figure out what role each factor plays. There are four different types of lupus: Lupus Erythematosus (LE), Lupus Vulgaris, Neonatal Lupus, and Subacute Cutaneous Lupus Erythematosus (SCLE). Lupus Erythematosus as two different areas, which are Discoid LE and Systemic LE. Discoid LE is the skin ... form, while Systemic LE is the internal form. Lupus Vulgaris is actually tuberculosis of the skin, while Neonatal Lupus is a rare type of lupus that aff...

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4. Lupus

... are three different types of lupus: discoid, systematic, and drug-induced. Discoid lupus is just limited to the skin. Sufferers usually only have a rash on their face, neck, and scalp. Since discoid lupus just affects the skin, none of the body's internal organs are involved. Ten percent of patients with discoid lupus eventually acquire what is called systemic lupus erythematosus (SLE). Systemic lupus erythematosus is the form of the disease ... that most people are referring to when they mention "lupus." The word "systemic" means that this disease can affect any organ or system of the ...

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  • Approx Pages: 4
  • Grade Level: High School

5. Arthritis

... , and stiffness. It can be mild and disappear after several years, or in severe cases, JRA can be chronic and last a lifetime. Another autoimmune disorder, systemic lupus erythematosus, commonly known as lupus, is an arthritis-related condition causing fever, rash, and swelling of the joints. Lupus can have serious complications, including inflammation of the lungs, kidneys, brain, bone marrow, and the lining of the heart ... . Lupus affects about 500,000 to 1.5 million Americans and is most common in young women aged 15 to 40. Females are nine times more likely than males to develop the ...

  • Word Count: 1806
  • Approx Pages: 7
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6. Arthritus

... , and stiffness. It can be mild and disappear after several years, or in severe cases, JRA can be chronic and last a lifetime. Another autoimmune disorder, systemic lupus erythematosus, commonly known as lupus, is an arthritis-related condition causing fever, rash, and swelling of the joints. Lupus can have serious complications, including inflammation of the lungs, kidneys, brain, bone marrow, and the lining of the heart ... . Lupus affects about 500,000 to 1.5 million Americans and is most common in young women aged 15 to 40. Females are nine times more likely than males to develop the ...

  • Word Count: 1635
  • Approx Pages: 7
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7. Hygiene Hypothesis - Too Clean for Good Health

... hay fever, asthma, and eczema, and thus, hygiene hypothesis was born (8). In more recent years, some scientists have even proposed a correlation between hygiene hypothesis and many other autoimmune diseases, including lupus, type one diabetes, and even cancer. In order to understand hygiene hypothesis, the human immune system must be discussed. Every living organism is at risk of disease and infection, and ... body mass index. Type one diabetes mellitus destroys certain cells in the pancreas, resulting in a deficit of insulin and inability to use sugars, potentially leading to life thre...

  • Word Count: 3045
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8. Analysis of A Good Man is Hard to Find

... mysterious ways that God works through human beings. While O'Connor was growing up she had the hardship of having to take care of her sick father. "He died of systemic lupus erythematosus, a chronic autoimmune disease that attacks otherwise healthy tissues and organs. O'Connor was devastated by the loss of her father, one of the closest relationships in her life" (Shmoop). Perhaps ... ...

  • Word Count: 1229
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9. Osteoporosis and its Effects on Man

... muscles, joints, or fibrous tissue (Encarta 2001), and have been associated with an increase in bone loss. Two specific rheumatologic conditions that have been linked to accelerated bone loss are systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). SLE is an autoimmune disorder that causes inflammation in the body, especially in the joints, skin, and other tissues and organs ("Secondary" 1). Studies have found ... ...

  • Word Count: 3699
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