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Systemic Lupus Erythematosus

Also T cells obtained from females having achieved menopause did not show any significant sensitivity towards intracellular Calcineurin (Rider et al, 1998). This experiment was successful in proving the fact that it is female hormone estrogen that makes female more susceptible to acquire autoimmune disease such as SLE.
             Identification of the auto-antibodies involved in systemic lupus is very critical in understanding the way one's own antibody works against one's own cells (Lim et al, 2002). Auto-antibodies associated with Systemic Lupus Erythematosus remained unidentified until early 1990s, analyzing the nature and molecular working of the such auto-antibodies after its identification was still a challenge for the scientific community. Dr. Yoon Lim with team, at The Seoul National University, college of Medicine took the challenge. Sixty eight patients with age range of 26.5years to 55.5years while 78 normal people were used as controls. Samples of ploy (A)+ were collected from human kidney, human testis and human lung cancer cell. After obtaining the samples cDNA expression libraries were constructed. Each library was consisted approximately 2X106 primary recombinants on average and 5 x 105 of them were used for immunoscreening, CDNA expression libraries were screened with sera of ten patients of SLE. Once the immuneoscreenoing was done, the DNA of the sera-raective clones was purified (Lim et al, 2002). The clone sequencing was performed by using genetic analyzer automated sequencer. Serum of patients was used at a dilution of 1:250. The tested clones were easily distinguished from the control clones ,thus could be said to have auto-antibodies against the cell nuclei and cytoplasm (Lim et al, 2002).
             The experiment performed by Lim not only showed the presence of the auto-anitbodies against the cell nuclei and cytoplasm in the patients but also identified the exact nature and genetic location of such auto-antibodies (Lim et al, 2002).


Essays Related to Systemic Lupus Erythematosus

1. Lupus

There are four different types of lupus: Lupus Erythematosus (LE), Lupus Vulgaris, Neonatal Lupus, and Subacute Cutaneous Lupus Erythematosus (SCLE). Lupus Erythematosus as two different areas, which are Discoid LE and Systemic LE. Discoid LE is the skin form, while Systemic LE is the internal form. ... SCLE is a milder form of both discoid and systemic lupus. ... These include Anti-DNA antibodies, the Lupus Erythematosus cell preparation (LE Prep), Antibodies to Sm (Smith), and a false positive serologic test for syphilis. ...

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2. Symptoms and Treatments of Lupus

There are several types of lupus such as drug-induced lupus, subacute cutaneous lupus erythematosus, discoid lupus erythematosus, and systemic lupus erythematosus. Of the four types, systemic lupus erythematosus is found to be the most common ("Womens Health", 2009). ... The guide states that, "children as young as several months have been diagnosed with SLE (systematic lupus erythematosus)" (Wallace, 2008, p.11). ... To illustrate this statement, the author states, "approximately one white male in 10,000, one white female in 1,000 and one African American female in 25...

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3. The History Of Lupus

Introduction There is no more difficult disease to diagnose, understand, or treat than the disease called systemic lupus erythematosus (Lahita 1998). ... Most systemic lupus patients will develop arthritis some time during the course of their illness. ... Sometimes, arthritis of systemic lupus can mimic that of rheumatoid arthritis (JAMA 2001). ... criteria, the diagnosis of systemic lupus erythematosus is suggested (MedicineNet 2000). ... There is no permanent cure for systemic lupus. ...

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4. Lupus

Ten percent of patients with discoid lupus eventually acquire what is called systemic lupus erythematosus (SLE). Systemic lupus erythematosus is the form of the disease that most people are referring to when they mention "lupus." The word "systemic" means that this disease can affect any organ or system of the body. ... The third type of lupus is drug-induced lupus. ... Lupus is not a rare disease, yet the cause of lupus is still unknown. ...

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5. Arthritus

Another autoimmune disorder, systemic lupus erythematosus, commonly known as lupus, is an arthritis-related condition causing fever, rash, and swelling of the joints. Lupus can have serious complications, including inflammation of the lungs, kidneys, brain, bone marrow, and the lining of the heart. Lupus affects about 500,000 to 1.5 million Americans and is most common in young women aged 15 to 40. ... But unlike the inflammation in RA and lupus, which is related to the immune system, joint inflammation in gout is caused by deposits of sodium urate crystals in the joints. ...

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6. Arthritis

Another autoimmune disorder, systemic lupus erythematosus, commonly known as lupus, is an arthritis-related condition causing fever, rash, and swelling of the joints. Lupus can have serious complications, including inflammation of the lungs, kidneys, brain, bone marrow, and the lining of the heart. Lupus affects about 500,000 to 1.5 million Americans and is most common in young women aged 15 to 40. ... But unlike the inflammation in RA and lupus, which is related to the immune system, joint inflammation in gout is caused by deposits of sodium urate crystals in the joints. ...

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8. Hygiene Hypothesis - Too Clean for Good Health

Before the advent of good hygiene practices and successful antimicrobial agents, the rate of communicable disease was unimaginable compared to today's rate of disease. Comparatively, it is easy to see a difference in sanitary standards between the western and industrialized nations and the third wor...

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9. Osteoporosis and its Effects on Man

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