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Microbiology


The cell dies as a result. In the lysogenic cycle, the infected bacterium does not immediately produce viruses but may do so sometime in the future. In the meantime the phage is latent-not actively replicating. During the lysogenic cycle, the phage becomes a prophage that is integrated into the host genome. At a later time, the phage may reenter the lytic cycle and replicate itself. .
             Animal viruses replicate in a manner similar to bacteriophages, but there are modifications. If the virus has an envelope, its glycoprotein spikes allow the virus to adhere to plasma membrane receptors. Then the capsid and viral genome penetrate a host cell. After reaching the inside of the cell the virus is uncoated as the capsid is removed. The viral genome, either DNA or RNA, is now free of its coverings and biosynthesis proceeds. The other difference is that the viral release occurs by budding. Budding does not necessarily mean death for the host cell. After animal viruses enter the host cell, uncoating releases viral DNA or RNA, and replication occurs. If release is by budding, the viral particle acquires a membranous envelope. The enzyme reverse transcriptase allows retroviruses to produce a cDNA copy of their genes, which become integrated into the host genome. .
             Viruses are best known for causing infectious diseases in plants and animals, including humans. At least a thousand different viruses cause diseases in plants. About a dozen crop diseases have been attributed not to viruses but to viroids, which are naked strands of RNA not covered by a capsid. Like viruses, though, viroids direct the cell to produce more viroids. Some diseases in humans have been attributed to prions, which are protein particles that possibly can convert other proteins in the cell to become .
             prions. Recently, prions have been linked to a serious outbreak in Great Britain of bovine spongiform encephalopathy (BSE), better known as mad cow disease.


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