1. Social issues
... the outcome of a Sindbis virus infection in vivo, we converted Sindbis virus into a vector by inserting a cassette into the viral genome. This cassette contains a duplicated copy of the Sindbis virus subgenomic promoter to drive expression of proteins of interest. This virus vector, together with knockout mice, has allowed us to study the role of pro-apoptotic Bcl-2 family proteins Bax and Bak ... in modulating the outcome of a Sindbis virus infection. This work led to the unexpected finding that Baxand Bak can function as potent inhibitors of neuronal apoptosis in mice. We now support ...
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- Grade Level: Graduate