He called this the "fantastical experiment."" The only problem with this experiment was that Spemann didn't have a clue of how to do it. A very significant contribution came in 1944 when American Oswald Avery located the nucleic acid DNA as the carrier of genetic information, instead of proteins in the cell. Further insight into this concept came in 1950 when Alfred Hershey and Martha Chase used radioactively labeled E. coli to prove that DNA and not proteins had penetrated interior of cells and was the true carrier of heredity. In 1952, a significant event occurred, Robert Briggs and Thomas King cloned northern leopard frog using nuclear transfer. "The purpose of the experiment was to study the activation and deactivation of genes during cell development. Using a glass pipette with a width between the cell's nucleus and the cell's width, King removed the nucleus from a blastula cell, an embryo cell during the period in which the embryo is only about 16 thousand cells. The outer part of the cell was crushed and broke away as the nucleus is sucked into the pipette. A glass needle was then used to remove the egg's own nucleus, and was replace with the nucleus of the blastula cell. Finally, Briggs and King cloned 27 tadpoles from 104 nuclear transfers. Those few surviving tadpoles cloned from differentiated cells were abnormal, leading Briggs and King to believe that adult differentiated cells cannot be used to clone an organism."" (http://library.thinkquest.org/C0122429/history/1952.htm). In 1962, John Gurdon claimed to have cloned frogs from adult cells. His experiment demonstrated that cells retain the ability to form different tissues even after they specialize. Yet, mistakes were found in his work. "Dennis Smith pointed out that there were some undifferentiated sex cells in the intestines of South African frogs, so the tadpoles Gurdon cloned may very well be cloned from those undifferentiated cells.